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Rabbit Anti-ATPase Na+/ K+ beta 2 antibody
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. [provided by RefSeq, Jul 2008]
Function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known.
Subunit:
Composed of three subunits: alpha (catalytic), beta and gamma.
Subcellular Location:
Membrane; Single-pass type II membrane protein.
Similarity:
Belongs to the X(+)/potassium ATPases subunit beta family.
SWISS:
P14415
Gene ID:
482
Database links:
Entrez
Gene: 482 Human
Entrez Gene: 11932 Mouse
Entrez Gene: 24214 Rat
Omim: 182331 Human
SwissProt: P14415 Human
SwissProt: P14231 Mouse
SwissProt: P13638 Rat
Unigene: 643540 Human
Unigene: 235204 Mouse
Unigene: 10624 Rat
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