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Home > Product > Antibody > Rabbit Anti-IL13 antibody
Interleukin-13; Interleukin 13; Interleukin13; ALRH; BHR 1; BHR1; IL 13; IL-13; MGC116786; MGC116788; MGC116789; NC30; P600; Interleukin-13; T-cell activation protein P600; IL13_MOUSE; IL13_HUMAN.
Cat:
SL0560R
Species Reactivity：
Human,(predicted: Mouse,Rat,Dog,Pig,Cow,Sheep,)
Immunogen：
KLH conjugated synthetic peptide derived from mouse IL-13:45-56/131(mo)
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Paraformaldehyde-fixed, paraffin embedded (Human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (IL-13) Polyclonal Antibody, Unconjugated (SL0560R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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Product PDFs
Datasheet:


This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]


Function:
Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.

Subcellular Location:
Secreted.

DISEASE:
Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.

Similarity:
Belongs to the IL-4/IL-13 family.

SWISS:
P20109

Gene ID:
16163

Database links:

Entrez Gene: 3596 Human

Entrez Gene: 16163 Mouse

Entrez Gene: 116553 Rat

Omim: 147683 Human

SwissProt: P35225 Human

SwissProt: P20109 Mouse

SwissProt: P42203 Rat

Unigene: 845 Human

Unigene: 1284 Mouse

Unigene: 9921 Rat



Picture

Paraformaldehyde-fixed, paraffin embedded (Human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (IL-13) Polyclonal Antibody, Unconjugated (SL0560R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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