Rabbit Anti-IL17A antibody | Sunlong Medical

Home > Product > Antibody > Rabbit Anti-IL17A antibody

Interleukin-17A; CTLA-8; CTLA 8; CTLA8; Cytotoxic T lymphocyte associated antigen 8; Cytotoxic T lymphocyte associated serine esterase 8; IL 17A; IL-17A; IL-17; Interleukin 17; Interleukin-17; Interleukin 17A; Interleukin17; Interleukin17A; IL17_HUMAN; IL

Cat:

SL1183R

Species Reactivity：

Mouse,Rat,

Immunogen：

KLH conjugated synthetic peptide derived from mouse IL-17:85-150/150

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Sample: Lane 1: Rat Lymph node tissue lysates Lane 2: Mouse Lymph node tissue lysates Lane 3: Rat Thymus tissue lysatesPrimary: Anti-IL17A (SL1183R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 15 kDObserved band size: 22 kDTissue/cell: rat tongue tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,SLC0005) at 37℃ for 20 min; Incubation: Anti-IL-17/IL-17A Polyclonal Antibody, Unconjugated(SL1183R) 1:600, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(SLC0010) stainingTissue/cell: rat stomach tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,SLC0005) at 37℃ for 20 min; Incubation: Anti-IL-17/IL-17A Polyclonal Antibody, Unconjugated(SL1183R) 1:600, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(SLC0010) staining

prev next

Unit:

Price: $220.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoSLV2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A. [provided by RefSeq, Sep 2020]

Function:
Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.

Subunit:
Homodimer.

Subcellular Location:
Secreted.

Tissue Specificity:
Restricted to a subset of activated T-cells.

Post-translational modifications:
Found both in glycosylated and nonglycosylated forms.

Similarity:
Belongs to the IL-17 family.

SWISS:
Q62386

Gene ID:
16171

Database links:

Entrez Gene: 725 Human

Entrez Gene: 16171 Mouse

Entrez Gene: 301289 Rat

Omim: 603149 Human

SwissProt: Q16552 Human

SwissProt: Q62386 Mouse

SwissProt: Q61453 Rat

Unigene: 41724 Human

Unigene: 5419 Mouse

Unigene: 218513 Rat

白细胞介素17（IL-17A）是一种来源于活化T淋巴细胞的细胞因子,具有较广泛的生物学活性,它能够通过诱导基质细胞产生前炎性细胞因子和造血细胞因子参与机体免疫调节及部分炎症反应，因此白细胞介素IL-17A可能是某些疾病发生发展的重要因素之一。Interleukin-17 原称CTLA-8, 是T细胞表达的多肽，参与造血干系统的调节，已经显示IL-17促进纤维母细胞产生IL-6，IL-8和G-CSF。 Picture

Tissue/cell: rat tongue tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,SLC0005) at 37℃ for 20 min;
Incubation: Anti-IL-17/IL-17A Polyclonal Antibody, Unconjugated(SL1183R) 1:600, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(SLC0010) staining

Tissue/cell: rat stomach tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,SLC0005) at 37℃ for 20 min;
Incubation: Anti-IL-17/IL-17A Polyclonal Antibody, Unconjugated(SL1183R) 1:600, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(SLC0010) staining

Product Feedback Wall

Specific References (20) | SL1183R has been referenced in 20 publications.

[IF=4.36] An Wang. et al. Yiqi Jiedu herbal decoction attenuates the 2 Gy 60Co γ ray induced spleen injury by inhibiting apoptosis and modulating the immune balance. J Ethnopharmacol. 2022 Mar;286:114925 IHC ; Mouse.

PubMed:34933086

[IF=3.411] Zhou Yonglong. et al. Mechanism of Catechol-O-methyltransferase Regulating Orofacial Pain Induced by Tooth Movement. Biomed Res Int. 2021;2021:4229491 other ; Rat.

PubMed:34725639

[IF=6.048] Qingqing Liu. et al. Probiotics alleviate autoimmune hepatitis in mice through modulation of gut microbiota and intestinal permeability. J Nutr Biochem. 2021 Sep;:108863 IHC ; mouse.

PubMed:34517094

[IF=2.502] Pu J et al. FGF-7 facilitates the process of psoriasis by inducing TNF-α expression in HaCaT cells. Acta Biochim Biophys Sin (Shanghai). 2019 Sep 6;51(10):1056-1063. WB ; Mouse.

PubMed:31555794

[IF=1.396] Xiong Y et al. Functions of T-cell subsets and their related cytokines in the pathological processes of autoimmune encephalomyelitic mice.(2018) Int J Clin Exp Pathol;11(10):4817-4826. FC&IHC ; Mouse.

PubMed:ISSN:1936-2625/IJCEP0080924

[IF=-] Legembre P et al. Methods and pharmaceutical compositions for the treatment of th17 mediated diseases. IHSLCP ; Human.

PubMed:US2036298104A1

[IF=1.69] Liao, Yanxi, et al. "Promoting effects of IL‑23 on myocardial ischemia and reperfusion are associated with increased expression of IL‑17A and upregulation of the JAK2‑STAT3 signaling pathway." Molecular Medicine Reports. WB ; Rat.

PubMed:29039526

[IF=1.55] Yang, Lijuan, et al. "Effect of IL-17 in the development of colon cancer in mice." Oncology Letters 12.6 (2016): 4929-4936. WB ; Mouse.

PubMed:28101230

[IF=1.37] Yang, Xiao, et al. "Effect of Iodine Excess on Th1, Th2, Th17, and Treg Cell Subpopulations in the Thyroid of NOD. H-2h4 Mice." Biological Trace Element Research (2014): 1-9. IHSLCP ; Mouse.

PubMed:24740393

[IF=7] L.H. Frommherz. et al. Secukinumab for the treatment of SAM syndrome associated with desmoglein‐1 deficiency. 2020 Nov 18 IHC ; Human.

PubMed:3645394

[IF=5.279] Yan Zhang. et al. Ganoderic Acid A To Alleviate Neuroinflammation of Alzheimer’s Disease in Mice by Regulating the Imbalance of the Th17/Tregs Axis. J Agr Food Chem. 2021;69(47):14204–14214 WB ; Mouse.

PubMed:34798773

[IF=3.642] Emin Kaymak. et al. Thymoquinone has a neuroprotective effect against inflammation, oxidative stress, and endoplasmic reticulum stress in the brain cortex, medulla, and hippocampus due to doxorubicin. 2021 Aug 15 IHC ; Rat.

PubMed:34392583

[IF=3.69] Qingqing Chen. et al. Coptis chinensis Franch polysaccharides provide a dynamically regulation on intestinal microenvironment, based on the intestinal flora and mucosal immunity. J Ethnopharmacol. 2021 Mar;267:113542 IHC ; Rat.

PubMed:33152428

[IF=2.61] Wang N et al. CD226 attenuates Treg suppressive capacity via CTLA-4 and TIGIT during EAE. Immunol Res. 2019 Dec;67(6):486-496. IHSLCP ; Mouse.

PubMed:31919790

[IF=0] ES Yuksel et al. IL-17 and IL-22 in colitis associated colorectal cancer in mice. Medical Science. 2019 April 11,23(97). IHSLCP ; Mouse.

PubMed:ISSN:2321–7359

[IF=3.457] Zheng X et al. Dendritic cells and Th17/Treg ratio play critical roles in pathogenic process of chronic obstructive pulmonary disease. (2018) Biomedicine & Pharmacotherapy.108,1141–1151. IHC ; Human.

PubMed:30372815

[IF=1.922] Zhu C et al. Roseburia intestinalis inhibits interleukin‑17 excretion and promotes regulatory T cells differentiation in colitis.Mol Med Rep. 2018 Jun;17(6):7567-7574. IHSLCP ; Mouse.

PubMed:29620246

[IF=3.298] Qiu et al. Therapeutic Potential of Pien Tze Huang on Experimental Autoimmune Encephalomyelitis Rat. (2018) J.Immunol.Res. 2018:2952471 IHC ; Rat.

PubMed:29682587

[IF=2.55] Chen, Baiwen, et al. "Effects of 1, 25-dihydroxyvitamin D3 in an ovalbumin-induced allergic rhinitis model." International Immunopharmacology 47 (2017): 182-189. IHSLCF ; Mouse.

PubMed:28412624

[IF=4.03] Venkatasubramanian, Sambasivan, et al. "Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection." European Journal of Immunology (2015). IHSLCP ; Mouse.

PubMed:2647300