This gene encodes soluble NSF attachment protein gamma. The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused. The product of this gene mediates platelet exocytosis and controls the membrane fusion events of this process.[provided by RefSeq, Dec 2008]
Function:
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
Subcellular Location:
Membrane.
Similarity:
Belongs to the SNAP family.
SWISS:
Q99747
Gene ID:
8774
Database links:
Entrez Gene: 8774 Human
Entrez Gene: 108123 Mouse
Omim: 603216 Human
SwissProt: P81127 Cow
SwissProt: Q99747 Human
SwissProt: Q9CWZ7 Mouse
Unigene: 464622 Human
Unigene: 292687 Mouse
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Sample: Cerebrum (Mouse) Lysate at 40 ug
Primary: Anti- NAPG (SL19016R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 35 kD
Observed band size: 34 kD
Sample: Cerebellum (Mouse) Lysate at 40 ug
Primary: Anti- NAPG (SL19016R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 35 kD
Observed band size: 34 kD
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (NAPG) Polyclonal Antibody, Unconjugated (SL19016R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (NAPG) Polyclonal Antibody, Unconjugated (SL19016R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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