Rabbit Anti-Synaptophysin antibody

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Major synaptic vesicle protein P38; MRXSYP; Syn p38; SYP; SYPH; SYPH_HUMAN; SypI.

Cat:

SL23504R

Species Reactivity：

Human,Mouse,Rat,

Immunogen：

KLH conjugated synthetic peptide derived from human Synaptophysin :201-300/313<Cytoplasmic>

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Sample: Cerebrum (Mouse) Lysate at 40 ugCerebrum(Rat) Lysate at 40 ugPrimary: Anti- Synaptophysin (SL23504R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 34 kDObserved band size: 39 kDSample: Cerebrum (Rat) Lysate at 40 ugPrimary: Anti-Synaptophysin (SL23504R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 34 kDObserved band size: 39 kDSample: Cerebral cortex (Mouse) Lysate at 40 ugPrimary: Anti-Synaptophysin (SL23504R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 34 kDObserved band size: 39 kDSample: Jurkat(Human) Cell Lysate at 30 ugPrimary: Anti-Synaptophysin (SL23504R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 34 kDObserved band size: 39 kD

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR). [provided by RefSeq, Aug 2011]

Function:
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity.

Subcellular Location:
Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Cell junction > synapse > synaptosome.

Tissue Specificity:
Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.

Post-translational modifications:
Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.

DISEASE:
Defects in SYP are the cause of mental retardation X-linked SYP-related (MRXSYP) [MIM:300802]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.

Similarity:
Belongs to the synaptophysin/synaptobrevin family. Contains 1 MARVEL domain.

SWISS:
P08247

Gene ID:
6855

Database links:

Entrez Gene: 280937 Cow

Entrez Gene: 6855 Human

Entrez Gene: 20977 Mouse

Entrez Gene: 4964 Rat

Omim: 313475 Human

SwissProt: P20488 Cow

SwissProt: P08247 Human

SwissProt: Q62277 Mouse

SwissProt: P07825 Rat

Unigene: 632804 Human

Unigene: 223674 Mouse

Unigene: 11067 Rat

Picture

Sample:
Cerebrum (Rat) Lysate at 40 ug
Primary: Anti-Synaptophysin (SL23504R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 34 kD
Observed band size: 39 kD

Sample:
Cerebral cortex (Mouse) Lysate at 40 ug
Primary: Anti-Synaptophysin (SL23504R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 34 kD
Observed band size: 39 kD

Sample:
Jurkat(Human) Cell Lysate at 30 ug
Primary: Anti-Synaptophysin (SL23504R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 34 kD
Observed band size: 39 kD

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