Rabbit Anti-Myelin Protein Zero antibody

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peripheral myelin prothein Zero; MPZ; MPP; Myelin P0 protein; CHM; CMT1; CMT1B; DSS; MYELIN GLYCOPROTEIN P-ZERO; MYELIN PROTEIN PERIPHERAL; Myelin protein zero; P0; MYP0_HUMAN.

Cat:

SL0337R

Species Reactivity：

Mouse,Rat,Dog,(predicted: Human,Pig,Cow,Horse,Rabbit,Guinea Pig,)

Immunogen：

KLH conjugated synthetic peptide derived from human P0 protein:175-248/248<Cytoplasmic>

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Sample: Spinal cord (Rat) Lysate at 40 ugPrimary: Anti- Myelin Protein Zero (SL0337R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 24 kDObserved band size: 29 kDSample: Lane 1: Spinal cord (Mouse) Lysate at 40 ugLane 2: Spinal cord (Rat) Lysate at 40 ugLane 3: Adipose (Mouse) Lysate at 40 ugLane 4: Adipose (Rat) Lysate at 40 ugPrimary: Anti-Myelin Protein Zero (SL0337R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 28 kDObserved band size: 28 kDSample: Bone (Mouse) Lysate at 40 ugPrimary: Anti-Myelin Protein Zero (Bs- 0337R) at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 24 kDObserved band size: 26 kD

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Unit:

Price: $220.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Myelin protein-zero is the major structural protein of peripheral myelin, accounting for more than 50% of the protein present in the sheath of peripheral nerves. Expression of the gene encoding Myelin protein-zero (MPZ) is restricted to Schwann cells; MPZ is not found in the CNS. An integral membrane glycoprotein of ~28kDa, Myelin protein-zero is thought to link adjacent lamellae and thereby stabilize the myelin assembly. The other 3 major components of myelin are myelin basic protein, myelin proteolipid protein and myelin-associated glycoprotein.

Subunit:
Homodimer and homotetramer.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein.

Tissue Specificity:
Found only in peripheral nervous system Schwann cells.

Similarity:
Belongs to the myelin P0 protein family.
Contains 1 Ig-like SLVtype (immunoglobulin-like) domain.

SWISS:
P25189

Gene ID:
4359

Database links:

Entrez Gene: 4359 Human

Entrez Gene: 17528 Mouse

Omim: 15988 Human

SwissProt: P25189 Human

SwissProt: P27573 Mouse

Unigene: 591486 Human

Unigene: 93883 Human

Unigene: 9986 Mouse

UniProtKB/Swiss-Prot: P25189.1

成熟的周围神经系统髓鞘主要的蛋白为P0蛋白，分子量28KDa，它具有单个跨膜区，是IgG超家族的成员之一。 Picture

Sample:
Lane 1: Spinal cord (Mouse) Lysate at 40 ug
Lane 2: Spinal cord (Rat) Lysate at 40 ug
Lane 3: Adipose (Mouse) Lysate at 40 ug
Lane 4: Adipose (Rat) Lysate at 40 ug
Primary: Anti-Myelin Protein Zero (SL0337R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 28 kD
Observed band size: 28 kD

Sample:
Bone (Mouse) Lysate at 40 ug
Primary: Anti-Myelin Protein Zero (Bs- 0337R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 24 kD
Observed band size: 26 kD

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