CAMTA1 is a transcription activator which is a putatuove tumor suppressor. It is thought to interact with calmodulin. Defects in CAMTA1 are detected in patients with oligodendroglioma and astrocytoma.
Function:
Transcriptional activator. May act as a tumor suppressor.
Subunit:
May interact with calmodulin (Potential).
Subcellular Location:
Nucleus (Probable). Cytoplasm.
Tissue Specificity:
Normally expressed in non-neoplastic adult central nervous system tissues: detected in whole brain, cerebellum, brain cortex, occipital lobe, frontal lobe, temporal lobe, putamen. Expression levels are low in oligodendroglial tumors, and are reduced by half in oligodendroglioma and astrocytoma cases with 1p loss of heterozygosity. Detected in neuroblastic-type cultured neuroblastoma cells. Expressed in heart and kidney.
Similarity:
Belongs to the CAMTA family.
Contains 3 ANK repeats.
Contains 1 CG-1 DNA-binding domain.
Contains 1 IPT/TIG domain.
Contains 3 IQ domains.
SWISS:
Q9Y6Y1
Gene ID:
23261
Database links:
Entrez Gene: 23261 Human
Entrez Gene: 100072 Mouse
Omim: 611501 Human
SwissProt: Q9Y6Y1 Human
SwissProt: A2A898 Mouse
Unigene: 397705 Human
Unigene: 671020 Human
Unigene: 318846 Mouse
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Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CAMTA1) Polyclonal Antibody, Unconjugated (SL5995R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CAMTA1) Polyclonal Antibody, Unconjugated (SL5995R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Image was kindly submitted by Dr. Luan Zhou at the University of Massachusetts Medical School. Frozen mouse retina stained with Rabbit Anti-CAMTA1 Polyclonal Antibody (SL5995R)
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