FA64A_HUMAN; FAM64A; family with sequence similarity 64, member A; FLJ10156; FLJ10491; Protein FAM64A; RCS1; regulator of chromosome segregation 1; PIMREG; CALM-interactor expressed in thymus and spleen; PICALM-interacting mitotic regulator; Regulator of
Cat:
SL11005R
Species Reactivity：
Mouse,(predicted: Human,Rat,Pig,Horse,)
Immunogen：
KLH conjugated synthetic peptide derived from human RCS1/FAM64A:151-248/248
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000ELISA=1:5000-10000not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Sample: Thymus (Mouse) Lysate at 40 ugSpleen (Mouse) Lysate at 40 ugPrimary: Anti- FAM64A (SL11005R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 27 kDObserved band size: 25 kDSample: Thymus(Mouse) Lysate at 40 ugPrimary: Anti- FAM64A (SL11005R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 27 kDObserved band size: 27/26 kDSample: Ovary (Mouse) Lysate at 40 ugPrimary: Anti- FAM64A (SL11005R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 27 kDObserved band size: 27/26 kD
PIMREG (PICALM Interacting Mitotic Regulator) is a Protein Coding gene. Diseases associated with PIMREG include Suppurative Periapical Periodontitis.
Function: During mitosis, may play a role in the control of metaphase-to-anaphase transition.
Subunit: Isoform 1 and isoform 2 interact with PICALM; this interaction may target PICALM to the nucleus (PubMed:16491119). During mitosis, associates with HDAC2 and MTA2 subunits of the chromatin-remodeling NuRD complex; this association is strongest at prometaphase and decreases as the cell progresses through metaphase and anaphase (PubMed:18757745).
Subcellular Location: Nucleus
Tissue Specificity: Expressed in thymus (at protein level). Detected in spleen, colon, ovary and small intestines.
Post-translational modifications: Ubiquitinated by the anaphase-promoting complex/cyclosome (APC/C) complex in the presence of FZR1, leading to its degradation by the proteasome during mitotic exit. However, degradation is not essential for normal mitotic progression within a single cell cycle.
Sample:
Thymus (Mouse) Lysate at 40 ug
Spleen (Mouse) Lysate at 40 ug
Primary: Anti- FAM64A (SL11005R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 27 kD
Observed band size: 25 kD
Sample:
Thymus(Mouse) Lysate at 40 ug
Primary: Anti- FAM64A (SL11005R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 27 kD
Observed band size: 27/26 kD
Sample:
Ovary (Mouse) Lysate at 40 ug
Primary: Anti- FAM64A (SL11005R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 27 kD
Observed band size: 27/26 kD
