NEGR1 is a 354 amino acid protein belonging to the IgLON family and immunoglobulin superfamily. NEGR1 may play a role in cell adhesion and regenerative axon sprouting in the mammalian brain and is highly expressed in adult hippocampus, cerebrum and brainstem, with much lower levels found in cerebellum. Localizing to the cell membrane at the glycosylphosphatidylinositol anchor (GPI) anchor, NEGR1 contains three Ig-like C2-type (immunoglobulin-like) domains. NEGR1 is encoded by a gene that maps to human chromosome 1p31.1, and is one of several loci associated with body mass index (BMI), possibly contributing to the development of obesity.
Function:
NEGR1 may be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain.
Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor
Similarity:
Belongs to the immunoglobulin superfamily. IgLON family.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
SWISS:
Q7Z3B1
Gene ID:
257194
Database links:
Entrez Gene: 257194 Human
Entrez Gene: 64168 Mouse
Entrez Gene: 59318 Rat
Omim: 613173 Human
SwissProt: Q7Z3B1 Human
SwissProt: D3Z4T6 Mouse
SwissProt: D4A2V0 Rat
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Sample:
Muscle (Mouse) Lysate at 40 ug
Primary: Anti-NEGR1 (SL11095R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 31 kD
Observed band size: 37 kD
Sample:
Cerebellum (Mouse) Lysate at 40 ug
Primary: Anti-NEGR1 (SL11095R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 31 kD
Observed band size: 37 kD
Sample:
Brain (Mouse) Lysate at 40 ug
Primary: Anti-NEGR1 (SL11095R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 31 kD
Observed band size: 37 kD
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