Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.
Function:
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).
Subunit:
Interacts as a tetramer with GABRB1 and GABRB2 (By similarity).
Subcellular Location:
Cell junction > synapse > presynaptic cell membrane. Cell junction > synapse > postsynaptic cell membrane.
Similarity:
Contains 1 BTB (POZ) domain.
SWISS:
Q6ZWB6
Gene ID:
386617
Database links:
Entrez Gene: 386617 Human
Entrez Gene: 243043 Mouse
SwissProt: Q6ZWB6 Human
SwissProt: Q50H33 Mouse
Unigene: 479644 Human
Unigene: 234821 Mouse
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Sample: Liver (Mouse) Lysate at 40 ug
Primary: Anti-KCTD8 (SL12087R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 52kD
Observed band size: 52kD
Sample: Brain (Mouse) Lysate at 40 ug
Primary: Anti-KCTD8 (SL12087R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 52kD
Observed band size: 52kD
Sample: Du145 Cell (Human) Lysate at 30 ug
Primary: Anti-KCTD8 (SL12087R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 52kD
Observed band size: 52kD
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