GPCR TAS1R3; Sweet taste receptor T1R3; T1 R3; T1R 3; T1R3; TAS1 R3; TAS1R 3; TAS1R3; Taste receptor type 1 member 3; Taste receptor type 1 member 3 precursor; TR 3; TR3; TS1R3_HUMAN.
Cat:
SL23618R
Species Reactivity：
Human,Mouse,
Immunogen：
KLH conjugated synthetic peptide derived from human TAS1R3:431-530/852<Extracellular>
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Sample: HUVEC(Human) Cell Lysate at 30 ugPrimary: Anti-TAS1R3 (SL23618R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 92 kDObserved band size: 122 kDSample: Liver (Mouse) Lysate at 40 ugPrimary: Anti- TAS1R3 (SL23618R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 92 kDObserved band size: 100 kDSample: A431(Human) Cell Lysate at 30 ugK562(Human) Cell Lysate at 30 ugPrimary: Anti-TAS1R3 (SL23618R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 92 kDObserved band size: 122 kD
The TAS1R3 gene encodes the human homolog of mouse Sac, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharine, and other sweeteners (Max et al., 2001 [PubMed 11326277]).[supplied by OMIM, Jan 2010].
Function: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.
Subunit: Forms homodimers or heterodimers with TAS1R1 and TAS1R2.
Tissue Specificity: Expressed in vascular endothelium.
Post-translational modifications: Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK7/PAK5. Dephosphorylated by PTPRJ.
Similarity: Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.
Sample:
HUVEC(Human) Cell Lysate at 30 ug
Primary: Anti-TAS1R3 (SL23618R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 92 kD
Observed band size: 122 kD
Sample:
Liver (Mouse) Lysate at 40 ug
Primary: Anti- TAS1R3 (SL23618R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 92 kD
Observed band size: 100 kD
Sample:
A431(Human) Cell Lysate at 30 ug
K562(Human) Cell Lysate at 30 ug
Primary: Anti-TAS1R3 (SL23618R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 92 kD
Observed band size: 122 kD
