Home > Product > Antibody > Rabbit Anti-ARC antibody
ARG3.1; Arc; Arg 3.1; Activity regulated cytoskeletal associated protein; Activity regulated cytoskeletal protein; Activity-regulated cytoskeleton-associated protein; Activity regulated cytoskeletal-associated protein; ARC/ARG3.1; Activity-regulated gene
Cat:
SL0385R
Species Reactivity:
Human,Rat,(predicted: Mouse,Cow,Horse,Rabbit,)
Immunogen:
KLH conjugated synthetic peptide derived from human ARC:101-200/396
Format:
Liquid
Storage instructions:
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration:
1mg/ml
Clonality:
Polyclonal
Isotype:
IgG
Applications:
WB=1:500-2000ELISA=1:5000-10000Flow-Cyt=1μg /testnot yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host:
Rabbit
Product Overview:
Sample: Brain (Rat) Lysate at 40 ugBrain (Mouse) Lysate at 40 ugPrimary: Anti-ARC (SL0385R) at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 45 kDObserved band size: 45 kDCell: A549Concentration:1:100Host/Isotype:Rabbit/IgGFlow cytometric analysis of primary antibody (Cat#: SL0385R) on A549(green) compared with isotype control in the absence of primary antibody (blue) followed by Alexa Fluor 488-conjugated goat anti-rabbit IgG(H+L) secondary antibody .
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Unit:
Price: $
Product PDFs
Datasheet:


Activity-regulated cytoskeleton-associated protein (ARC)in the brain and learning and memory, researchers believe: ARC protein is by strengthening the function of synaptic links in order to save the memory, including learning and memory and emotion. At present, the scientists will also Activity-regulated cytoskeleton-associated protein used to take drugs addiction.

Function:
Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration.

Subunit:
Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2.

Subcellular Location:
Cytoplasm, cytoskeleton. Endosome. Cytoplasmic vesicle, secretory vesicle, acrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse.

Similarity:
Belongs to the ARC/ARG3.1 family.

SWISS:
Q7LC44

Gene ID:
23237

Database links:

Entrez Gene: 23237 Human

Entrez Gene: 11838 Mouse

Entrez Gene: 54323 Rat

Omim: 605235 Human

SwissProt: Q7LC44 Human

SwissProt: Q9WV31 Mouse

SwissProt: Q63053 Rat

Unigene: 40888 Human

Unigene: 741621 Human

Unigene: 25405 Mouse

Unigene: 10086 Rat



该蛋白与大脑的学习记忆有关,研究人员认为:是ARC蛋白通过加强了突触的联系功能从而储存了这些记忆,包括情感和学习记忆。
目前,科学家也将该蛋白用于吸食毒品成瘾性的研究。 Picture

Sample:
Brain (Rat) Lysate at 40 ug
Brain (Mouse) Lysate at 40 ug
Primary: Anti-ARC (SL0385R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 45 kD
Observed band size: 45 kD
Cell: A549
Concentration:1:100
Host/Isotype:Rabbit/IgG
Flow cytometric analysis of primary antibody (Cat#: SL0385R) on A549(green) compared with isotype control in the absence of primary antibody (blue) followed by Alexa Fluor 488-conjugated goat anti-rabbit IgG(H+L) secondary antibody .
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