Rabbit Anti-FGF10 antibody | Sunlong Medical

Home > Product > Antibody > Rabbit Anti-FGF10 antibody

Fibroblast growth factor 10; FGF 10; FGF-10; Keratinocyte growth factor 2; KGF 2; BB213776; fd11d03; FGF10_HUMAN; wu:fd11d03; zgc:109774.

Cat:

SL1326R

Species Reactivity：

Human,(predicted: Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep,Guinea Pig,)

Immunogen：

KLH conjugated synthetic peptide derived from human FGF10:101-208/208

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Sample: SW96 (human)cell Lysate at 40 ugPrimary: Anti-FGF10(SL1326R)at 1/300 dilutionSecondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilutionPredicted band size: 23 kDObserved band size: 17 kDSample:U251 (human)cell Lysate at 40 ugPrimary: Anti-FGF10(SL1326R)at 1/300 dilutionSecondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilutionPredicted band size: 23 kDObserved band size: 18 kD

prev next

Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]

Function:
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.

Subunit:
Interacts with FGFR1 and FGFR2. Interacts with FGFBP1.

Subcellular Location:
Secreted (Potential).

DISEASE:
Defects in FGF10 are the cause of autosomal dominant aplasia of lacrimal and salivary glands (ALSG) [MIM:36920]. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular and sublingual glands and absence of the lacrimal puncta. The disorder is characterized by irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which increases the risk of dental erosion, dental caries, periodontal disease and oral infections. Defects in FGF10 are a cause of lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]; also known as Levy-Hollister syndrome. LADDS is a form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. LADDS is an autosomal dominant syndrome characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed.

Similarity:
Belongs to the heparin-binding growth factors family.

SWISS:
O15520

Gene ID:
2255

Database links:

Entrez Gene: 2255 Human

Entrez Gene: 14165 Mouse

Entrez Gene: 25443 Rat

Omim: 602115 Human

SwissProt: O15520 Human

SwissProt: O35565 Mouse

SwissProt: P70492 Rat

Unigene: 664499 Human

Unigene: 317323 Mouse

Unigene: 44439 Rat

FGF-10对于角质形成细胞的异常增殖和分化异常可能有着重要的调节作用。有学者认为；部分肿瘤、胚胎发育紊乱、生长发育障碍性疾病、炎症及修复异常、免疫性疾病、血液病、HIV感染等都与FGF-10有关。 Picture

Sample:U251 (human)cell Lysate at 40 ug
Primary: Anti-FGF10(SL1326R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 23 kD
Observed band size: 18 kD

Product Feedback Wall