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Home > Product > Antibody > Rabbit Anti-Macrophage Inflammatory Protein 3 alpha antibody
Beta-chemokine exodus-1; C-C motif chemokine 20; CC chemokine LARC; CCL20; CCL20(2-70); CCL20_HUMAN; Chemokine (C C motif) ligand 20; Chemokine CC motif ligand 20; CKb4; Exodus 1; LARC; Liver and activation-regulated chemokine; Macrophage infl
Cat:
SL1268R
Species Reactivity：
Human,Mouse,(predicted: Rat,)
Immunogen：
KLH conjugated synthetic peptide derived from human CCL20:31-97/97
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Paraformaldehyde-fixed, paraffin embedded (human liver carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CCL20) Polyclonal Antibody, Unconjugated (SL1268R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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Product PDFs
Datasheet:


This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014].

Function:
Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. SLCterminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213.

Subunit:
Binds to and activate CCR6.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon.

Post-translational modifications:
SLCterminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes.

Similarity:
Belongs to the intercrine beta (chemokine CC) family.

SWISS:
O89093

Gene ID:
6364

Database links:

Entrez Gene: 6364 Human

Entrez Gene: 20297 Mouse

Entrez Gene: 29538 Rat

Omim: 601960 Human

SwissProt: P78556 Human

SwissProt: O89093 Mouse

SwissProt: P97884 Rat

Unigene: 75498 Human

Unigene: 116739 Mouse

Unigene: 10722 Rat



Picture

Paraformaldehyde-fixed, paraffin embedded (human liver carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CCL20) Polyclonal Antibody, Unconjugated (SL1268R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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