A family of resistin-like molecules (RELMs) has been identified in rodents and humans. RELM alpha belongs to a unique family of tissue-specific cytokines termed FIZZ (found in inflammatory zone) and RELM. The three known members of this family; Resistin, RELM alpha and RELM beta are 85-94 amino acid secreted proteins sharing a conserved SLCterminal domain. RELM alpha and Resistin are secreted exclusively by adipocytes while RELM beta is expressed in the epithelium of the colon and small bowel. The RELMs together with resistin comprise a class of tissue-specific signaling molecules. The physiological role and molecular targets of RELM alpha are still unknown.
Function: Probable hormone. Plays a role in pulmonary vascular remodeling.
Subunit: Monomer.
Subcellular Location: Secreted.
Tissue Specificity: Highest levels in adipose tissue.
Sample:
Liver (Mouse) Lysate at 40 ug
Primary: Anti- RELM alpha (SL1884R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 9 kD
Observed band size: 15 kD
Sample:
Liver (Mouse) Lysate at 40 ug
Primary: Anti-RELM alpha (SL1884R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 9 kD
Observed band size: 14 kD
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Specific References (1) | SL1884R has been referenced in 1 publications.
[IF=0.9] Chunyan, Lin, et al. "Effect of cigarette smoke extraction on the expression of found in inflammatory zone 1 in rat lung epithelial L2 cells." Chinese Medical Journal 127.12 (2014): 2363-2367. Rat.
