TNFRSF14 is a type I membrane protein belonging to the TNF receptor superfamily. This receptor mediates herpes virus entry into cells during infection. TNFRSF14 is able to inhibit the proliferation, activation, and cytokine production of T cells. It has an extracellular domain containing several cysteine-rich repeats and a short cytoplasmic region containing a TRAF (TNF receptor-associated factor) interaction domain. The extracellular domain of TNFRSF14 interacts with the herpes simplex virus envelope glycoprotein D. TNFRSF14 binds two cellular ligands: lymphotoxin alpha and LIGHT. LIGHT is a transmembrane protein expressed and shed from the surface of activated T cells, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes. The LIGHT:TNFRSF14 interaction controls immune response functions by cell death induction as well as cell activation. TNFRSF14 is expressed by peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells.
Function:
Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.
Subunit:
Interacts with TRAF2, TRAF3 and TRAF5. Interacts with herpes simplex virus 1 (HHSLV1) and herpes simplex virus 1 (HHSLV2) envelope glycoprotein D; functions as an entry receptor for these viruses.
Subcellular Location:
Membrane; Single-pass type I membrane protein
Tissue Specificity:
Widely expressed, with the highest expression in lung, spleen and thymus.
Post-translational modifications:
N-glycosylated.
Similarity:
Contains 3 TNFR-Cys repeats.
SWISS:
Q92956
Gene ID:
8764
Database links:
Entrez Gene: 8764 Human
Entrez Gene: 230979 Mouse
Omim: 602746 Human
SwissProt: Q92956 Human
Unigene: 512898 Human
Unigene: 215147 Mouse
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