Rabbit Anti-CD226 antibody | Sunlong Medical

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DNAX accessory molecule 1; adhesion glycoprotein; CD226 antigen; DNAM1; platelet and T cell activation antigen 1; PTA1; TLiSA1; CD226; CD226 molecule; CD226_HUMAN; DNAM 1; DNAM-1; T lineage specific activation antigen 1 antigen.

Cat:

SL2569R

Species Reactivity：

Human,Mouse,(predicted: Rat,Pig,Cow,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human CD226:201-300/336<Extracellular>

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000Flow-Cyt=1μg/Testnot yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Sample: Jurkat(Human) Cell Lysate at 30 ugPrimary: Anti-CD226 (SL2569R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 35 kDObserved band size: 35 kDBlank control(blue): Jurkat cells(fixed with 2% paraformaldehyde (10 min) ). Primary Antibody:Rabbit Anti-CD226 antibody(SL2569R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the SLVset. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. [provided by RefSeq, Jul 2008]

Subunit:
Interacts with PVR and PVRL2.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed by peripheral blood T-lymphocytes.

Similarity:
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

SWISS:
Q15762

Gene ID:
10666

Database links:

Entrez Gene: 10666 Human

Omim: 605397 Human

SwissProt: Q15762 Human

Unigene: 660130 Human

CD226分子是一种广泛表达于多种免疫细胞膜表面的Ⅰ型跨膜糖蛋白，CD226广泛表达于T细胞、NK细胞、NK T细胞、活化的血管内皮细胞、巨核/血小板谱系、单核细胞、胸腺细胞、某些B细胞亚群、部分造血干细胞和肥大细胞等免疫细胞表面，在免疫系统以外则分布于海马和小脑皮质的神经突触部位。CD226与其配体的相互作用参与CTL和NK细胞的活化、分化和细胞毒作用,调节CD4+ T细胞的增殖和分化，介导内皮细胞与其他细胞的黏附,促进血小板的活化与聚集，参与造血调控，介导肥大细胞的脱颗粒作用，参与NK T细胞和胸腺细胞的抗凋亡作用、树突状细胞的成熟、免疫突触和神经突触的形成，并与肿瘤、自身免疫性疾病、移植排斥及病毒感染等疾病密切相关。 Picture

Blank control(blue): Jurkat cells(fixed with 2% paraformaldehyde (10 min) ).
Primary Antibody:Rabbit Anti-CD226 antibody(SL2569R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA;
Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions );
Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.

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