Cysteine protease required for autophagy, which cleaves the SLCterminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed SLCterminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.
Function:
Cysteine protease required for autophagy, which cleaves the SLCterminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed SLCterminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.
Subcellular Location:
Cytoplasm (Probable).
Tissue Specificity:
Highly expressed in skeletal muscle, heart, liver and testis.
Similarity:
Belongs to the peptidase C54 family.
SWISS:
Q96DT6
Gene ID:
84938
Database links:
Entrez Gene: 84938 Human
Entrez Gene: 242557 Mouse
Entrez Gene: 313391 Rat
Omim: 611339 Human
SwissProt: Q96DT6 Human
SwissProt: Q811C2 Mouse
Unigene: 7353 Human
Unigene: 241663 Mouse
Unigene: 23378 Rat
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Sample:
Liver (Mouse) Lysate at 40 ug
Primary: Anti-ATG4C (SL4008R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 52 kD
Observed band size: 55 kD
Sample:
A673(Human) Cell Lysate at 30 ug
Primary: Anti-ATG4C (SL4008R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 52 kD
Observed band size: 55 kD
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