ACSVL1; FACVL1; FATP 2; FATP2; Fatty acid coenzyme A ligase, very long chain 1; Fatty acid transport protein 2; hFACVL1; HsT17226; Long chain fatty acid CoA ligase; Solute carrier family 27 (fatty acid transporter), member 2; Solute carrier family 27 memb
SLC27A2 is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long chain fatty acids into fatty acyl-CoA esters, and thereby may play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives.
Function: Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity).
Specific References (1) | SL3936R has been referenced in 1 publications.
[IF=2.559] Weinheimer C et al. Maternal Tobacco Smoke Exposure Causes Sex-Divergent Changes in Placental Lipid Metabolism in the Rat. Reprod Sci. 2020 Jan 6. WB ; Rat.
