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Home > Product > Antibody > Rabbit Anti-IGFBP7 antibody
AGM; Angiomodulin; FSTL2; IBP-7; IBP7; IBP7_HUMAN; IGF binding protein 7; IGF-binding protein 7; IGFBP rP1; IGFBP-7; IGFBP-rP1; IGFBP7; IGFBPRP1; Insulin like growth factor binding protein 7; Insulin-like growth factor-binding protein 7; MAC25; MAC25 prot
Cat:
SL5098R
Species Reactivity：
Human,Rat,(predicted: Mouse,Dog,Cow,Sheep,)
Immunogen：
KLH conjugated synthetic peptide derived from human IGFBP7:131-230/282
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Independently Validated Antibody, image provided by Science Direct, badge number 02663:Formalin-fixed and paraffin embedded human liver labeled with Anti-IGFBP7 Polyclonal Antibody, Unconjugated (SL5098R) at 1:250 overnight at 25C followed by conjugation to the secondary antibody and DAB staining. Positive Control has great staining, however it may be nonspecific.Independently Validated Antibody, image provided by Science Direct, badge number 02663:Formalin-fixed and paraffin embedded human kidney labeled with Anti-IGFBP7 Polyclonal Antibody, Unconjugated (SL5098R) at 1:250 overnight at 25C followed by conjugation to the secondary antibody and DAB staining. Postive Control has great staining, however it may be nonspecific.
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Product PDFs
Datasheet:


IGF-BPs form high affinity complexes with both IGF-I and IGF-II and act to control of the distribution, function and activity of IGFs in various cell tissues and body fluids. There are seven named IGF-BPs. IGFBP7 plays a role in skeletal myogenesis by binding to IGF in a manner that inhibits IGF induced differentiation of skeletal myoblasts, without affecting IGF induced proliferation. Additionally, IGFBP7 suppresses growth and colony formation of prostate and breast cancer cell lines through an IGF independent mechanism, which causes a delay in the G1 phase of the cell cycle, and increased apoptosis. IGFBP7 is expressed in a wide range of normal human tissues and it usually shows reduced expression in cancer cell lines of prostate, breast, colon, and lung origin.

Function:
Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.

Subunit:
May interact with VPS24/CHMP3; the relevance of such interaction however remains unclear.

Subcellular Location:
Secreted.

Post-translational modifications:
N-glycosylated.

DISEASE:
Defects in IGFBP7 are the cause of retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS) [MIM:614224]. RAMSVPS is an autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction.

Similarity:
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 IGFBP N-terminal domain.Contains 1 Kazal-like domain.

SWISS:
Q16270

Gene ID:
3490

Database links:

Entrez Gene: 3490 Human

Entrez Gene: 29817 Mouse

Entrez Gene: 289560 Rat

Omim: 602867 Human

SwissProt: Q16270 Human

SwissProt: Q61581 Mouse

Unigene: 471968 Human

Unigene: 233470 Mouse

Unigene: 203012 Rat



Picture

Independently Validated Antibody, image provided by Science Direct, badge number 02663:Formalin-fixed and paraffin embedded human liver labeled with Anti-IGFBP7 Polyclonal Antibody, Unconjugated (SL5098R) at 1:250 overnight at 25C followed by conjugation to the secondary antibody and DAB staining. Positive Control has great staining, however it may be nonspecific.
Independently Validated Antibody, image provided by Science Direct, badge number 02663:Formalin-fixed and paraffin embedded human kidney labeled with Anti-IGFBP7 Polyclonal Antibody, Unconjugated (SL5098R) at 1:250 overnight at 25C followed by conjugation to the secondary antibody and DAB staining. Postive Control has great staining, however it may be nonspecific.
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