Rabbit Anti-TMPRSS4 antibody

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MT SP2; Membrane type serine protease 2; TMPRSS 4; TMPRSS3; Transmembrane protease, serine 4; Transmembrane serine protease 3; UNQ776/PRO1570; TMPS4_HUMAN.

Cat:

SL6286R

Species Reactivity：

Human,Mouse,(predicted: Rat,Dog,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human TMPRSS4:84-130/437<Extracellular>

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Sample:Epithelium (Mouse)Lysate at 40 ugPrimary: Anti-TMPRSS4(SL6286R)at 1/300 dilutionSecondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilutionPredicted band size: 48kDObserved band size: 60kDSample:A431 (Human)Cell Lysate at 40 ugPrimary: Anti-TMPRSS4(SL6286R)at 1/300 dilutionSecondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilutionPredicted band size: 48kDObserved band size: 55kD

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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TMPRSS4 is a member of the peptidase S1 family and contains 1 LDL receptor class A domain, 1 peptidase S1 domain and 1 SRCR domain. It is a probable membrane protease capable of activating ENaC and may process sodium channels in endothelial cells. TMPRSS4 is overexpressed in thyroid neoplasms, and splice variants in TMPRSS4 are thought to be linked with different cancers. Three named isoforms are produced by alternative splicing.

Function:
Probable protease. Seems to be capable of activating ENaC.

Subcellular Location:
Membrane; Single-pass type II membrane protein (Potential).

Tissue Specificity:
High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal gastrointestinal and urogenital tract.

Similarity:
Belongs to the peptidase S1 family.
Contains 1 LDL-receptor class A domain.
Contains 1 peptidase S1 domain.
Contains 1 SRCR domain.

SWISS:
Q9NRS4

Gene ID:
56649

Database links:

Entrez Gene: 451581 Chimpanzee

Entrez Gene: 489387 Dog

Entrez Gene: 101147411 Gorilla

Entrez Gene: 100071190 Horse

Entrez Gene: 56649 Human

Entrez Gene: 100390415 Marmoset (common)

Entrez Gene: 100436934 Orangutan

Omim: 606565 Human

SwissProt: Q9NRS4 Human

Unigene: 161985 Human

Picture

Sample:A431 (Human)Cell Lysate at 40 ug
Primary: Anti-TMPRSS4(SL6286R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 48kD
Observed band size: 55kD

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