Rabbit Anti-TLR7 antibody | Sunlong Medical

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TLR-7; PRO285; TLR 7; TLR7_HUMAN; Toll like receptor 7; Toll-like receptor 7; UNQ248.

Cat:

SL6601R

Species Reactivity：

Human,Mouse,Rat,(predicted: Dog,Pig,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human TLR7:461-560/1049<Extracellular>

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Sample: Brain (Mouse) Lysate at 40 ugSpleen (Mouse) Lysate at 40 ugPrimary: Anti-TLR7 (SL6601R) at 1/300 dilutionSecondary: HRP conjugated Goat-Anti-rabbit IgG (SL0295G-HRP) at 1/5000 dilutionPredicted band size: 121 kDObserved band size: 121 kDSample: Lane 1: Human THP-1(LPS) cell lysates Lane 2: Human THP-1 cell lysates Lane 3: Human Jurkat cell lysates Lane 4: Human MCF-7 cell lysates Lane 5: Human 293T cell lysates Primary: Anti-TLR7 (SL6601R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 121 kDaObserved band size: 65,121 kDa

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Unit:

Price: $220.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Function:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Subunit:
Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1.

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.

Tissue Specificity:
Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.

Similarity:
Belongs to the Toll-like receptor family.
Contains 27 LRR (leucine-rich) repeats.
Contains 1 TIR domain.

SWISS:
Q9NYK1

Gene ID:
51284

Database links:

Entrez Gene: 493686 Cow

Entrez Gene: 51284 Human

Entrez Gene: 170743 Mouse

Omim: 300365 Human

SwissProt: Q9NYK1 Human

SwissProt: P58681 Mouse

Unigene: 101913 Cow

Unigene: 659215 Human

Unigene: 23979 Mouse

Picture

Sample:
Lane 1: Human THP-1(LPS) cell lysates
Lane 2: Human THP-1 cell lysates
Lane 3: Human Jurkat cell lysates
Lane 4: Human MCF-7 cell lysates
Lane 5: Human 293T cell lysates
Primary: Anti-TLR7 (SL6601R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 121 kDa
Observed band size: 65,121 kDa

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