PANK4 belongs to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the physiological regulation of the intracellular coenzyme A (CoA) concentration. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues.
Function:
Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity).
Subunit:
Homodimer. Interacts with PKM (By similarity).
Subcellular Location:
Cytoplasm (Probable).
Tissue Specificity:
Ubiquitously expressed with higher expression in the muscle.
Similarity:
Belongs to the type II pantothenate kinase family.
SWISS:
Q9NVE7
Gene ID:
55229
Database links:
Entrez Gene: 55229 Human
Entrez Gene: 269614 Mouse
Entrez Gene: 171053 Rat
Omim: 606162 Human
SwissProt: Q9NVE7 Human
SwissProt: Q80YV4 Mouse
SwissProt: Q923S8 Rat
Unigene: 26156 Human
Unigene: 30042 Mouse
Unigene: 17321 Rat
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Paraformaldehyde-fixed, paraffin embedded (rat kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PANK4) Polyclonal Antibody, Unconjugated (SL8340R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PANK4) Polyclonal Antibody, Unconjugated (SL8340R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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