This gene encodes a member of the SLCtype lectin/SLCtype lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting.
Subcellular Location:
Membrane; Single pass type I membrane protein.
Similarity:
Contains 1 SLCtype lectin domain.
Contains 1 EGF-like domain.
SWISS:
Q86T13
Gene ID:
161198
Database links:
Entrez Gene: 161198 Human
SwissProt: Q86T13 Human
Unigene: 525307 Human
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Sample:
B16 Cell (Mouse) Lysate at 40 ug
DU145 Cell (Human) Lysate at 40 ug
Primary: Anti-EGFR5 (SL9813R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 49 kD
Observed band size: 53 kD
Blank control(blue):293T (fixed with 2% paraformaldehyde (10 min)). Primary Antibody:Rabbit Anti-EGFR5 antibody(SL9813R), Dilution: 1μg in 100μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
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