Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZDHHC1 (zinc finger, DHHSLCtype containing 1), also known as ZNF377 (zinc finger protein 377) or C16orf1, is a 485 amino acid multi-pass membrane protein that contains one DHHSLCtype zinc finger. Expressed in fetal heart, lung and kidney and also present in adult lung and pancreas, ZDHHC1 functions as a palmitoyltransferase that catalyzes the conversion of palmitoyl-CoA and protein-cysteine to S-palmitoyl protein and CoA. Like ZDHHC1, ZDHHC5, ZDHHC6, ZDHHC7 and ZDHHC18 each contain one DHHSLCtype zinc finger through which they convey palmitoyltransferase activity against a broad range of substrates, including H-Ras, SNAP 25 and GABAA R proteins.
Function:
Has palmitoyltransferase activity towards HRAS and LCK.
Subcellular Location:
Membrane; Multi-pass membrane protein
Similarity:
Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
Contains 1 DHHSLCtype zinc finger.
SWISS:
Q9NUE0
Gene ID:
84243
Database links:
Entrez Gene: 84243 Human
Entrez Gene: 503610 Mouse
Entrez Gene: 362613 Rat
SwissProt: Q9NUE0 Human
SwissProt: Q5Y5T2 Mouse
SwissProt: Q2TGJ1 Rat
Unigene: 523710 Human
Unigene: 331948 Mouse
Unigene: 203345 Rat
| Picture |
Sample:
Lymph node (Mouse) Lysate at 40 ug
Primary: Anti- ZDHHSLC18 (SL8641R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 42 kD
Observed band size: 42 kD
Sample:
Lung (Mouse) Lysate at 40 ug
Primary: Anti- ZDHHSLC18 (SL8641R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 42 kD
Observed band size: 42 kD
|
|
|
