Beta-taxilin promotes nerve regeneration and may be involved in intracellular vesicle transport. Expressed predominantly in cardiac and skeletal muscle, beta-taxilin binds to the coiled coil region of the syntaxin family members STX1A, STX3A, and STX4A. Beta- and gamma-taxilins, bind to the alpha subunit of the nascent polypeptide-associated complex (NAC) and affect its nuclear distribution, suggesting that the taxilin family is involved not only in the translational process through its interaction with NAC but also in the
transcriptional process through its interaction with alphaNAC alone.
Function:
Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic.
Subunit:
Binds to the SLCterminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A. Has a preference for STX1A.
Tissue Specificity:
Expressed in skeletal muscle.
Similarity:
Belongs to the taxilin family.
SWISS:
Q8N3L3
Gene ID:
167838
Database links:
Entrez Gene: 167838 Human
Entrez Gene: 378431 Mouse
Entrez Gene: 308622 Rat
Omim: 611438 Human
SwissProt: Q8N3L3 Human
SwissProt: Q8VBT1 Mouse
Unigene: 535820 Human
Unigene: 283493 Mouse
Unigene: 165855 Rat
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Sample: Muscle (Mouse) Lysate at 40 ug
Primary: Anti-TXLNB (SL12153R) at 1/300 dilution
Secondary: HRP conjugated Goat-Anti-rabbit IgG (SL0295G-HRP) at 1/5000 dilution
Predicted band size: 76 kD
Observed band size: 76 kD
Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TXLNB) Polyclonal Antibody, Unconjugated (SL12153R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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