Chromosome 1 open reading frame 170; RP11-54O7.8; Uncharacterized protein C1orf170; CA170_HUMAN.
Cat:
SL15036R
Species Reactivity：
Mouse,(predicted: Human,Rat,Cow,Rabbit,)
Immunogen：
KLH conjugated synthetic peptide derived from human C1orf170:601-696/696
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Sample: Uterus (Mouse) Lysate at 40 ugPrimary: Anti-C1orf170 (SL15036R) at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 72 kDObserved band size: 72 kDSample: Muscle (Mouse) Lysate at 40 ugTongue (Mouse) Lysate at 40 ugPrimary: Anti-C1orf170 (SL15036R) at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 72 kDObserved band size: 72 kD
Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf170 gene product has been provisionally designated C1orf170 pending further characterization. There are two isoforms of C1orf170 that are produced as a result of alternative splicing events.
SWISS: Q5SV97
Gene ID: 8968
Database links:
Entrez Gene: 8968 Human
SwissProt: Q5SV97 Human
Picture
Sample: Uterus (Mouse) Lysate at 40 ug
Primary: Anti-C1orf170 (SL15036R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 72 kD
Observed band size: 72 kD
Sample:
Muscle (Mouse) Lysate at 40 ug
Tongue (Mouse) Lysate at 40 ug
Primary: Anti-C1orf170 (SL15036R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 72 kD
Observed band size: 72 kD
