The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. The Zinc finger and BTB domain-containing protein 11 (ZBTB11) contains 1 BTB (POZ) domain and 12 C2H2-type zinc fingers suggesting a role in transcription regulation. The gene encoding ZBTB11 maps to chromosome 3, which contains over 1,100 genes. Notably, a chemokine receptor gene cluster and a variety of human cancer related loci reside on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells as well.
Function:
May be involved in transcriptional regulation.
Subcellular Location:
Nucleus.
Similarity:
Contains 1 BTB (POZ) domain.
Contains 12 C2H2-type zinc fingers.
SWISS:
O95625
Gene ID:
27107
Database links:
Entrez Gene: 27107 Human
Entrez Gene: 271377 Mouse
Entrez Gene: 304010 Rat
SwissProt: O95625 Human
Unigene: 301956 Human
Unigene: 655286 Human
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Sample: thymus (Mouse) Lysate at 40 ug
Primary: Anti-zbtb11(SL13564R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 119 kD
Observed band size: 119 kD
Sample: Spleen (Mouse) Lysate at 40 ug
Primary: Anti-zbtb11(SL13564R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 119 kD
Observed band size: 119 kD
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