UNR is a 798 amino acid protein that localizes to the cytoplasm and contains nine CDS (cold shock) domains. Existing as a component of the multi-protein autoregulatory ribonucleoprotein complex (ARC), UNR functions as an RNA-binding protein that is required for the initiation of rhinovirus RNA translation and is thought to be involved in translationally coupled mRNA turnover. UNR is expressed as two isoforms, designated long and short, and shares over 98% amino acid identity with its rat counterpart, suggesting a conserved role between species. The gene encoding UNR maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome.
Function:
RNA-binding protein. Required for internal initiation of translation of human rhinovirus RNA. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.
Subcellular Location:
Cytoplasm.
Similarity:
Contains 9 CSD (cold-shock) domains.
SWISS:
O75534
Gene ID:
7812
Database links:
Entrez Gene: 7812 Human
Entrez Gene: 513993 Cow
Entrez Gene: 229663 Mouse
Entrez Gene: 11736 Rat
Omim: 191510 Human
SwissProt: O75534 Human
SwissProt: Q91W50 Mouse
SwissProt: P18395 Rat
Unigene: 69855 Human
Unigene: 277713 Mouse
Unigene: 3562 Rat
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Tissue/cell: mouse embryo tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,SLC0005) at 37℃ for 20 min;
Incubation: Anti-CSDE1 Polyclonal Antibody, Unconjugated(SL14083R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(SLC0010) staining
Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,SLC0005) at 37℃ for 20 min;
Incubation: Anti-CSDE1 Polyclonal Antibody, Unconjugated(SL14083R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(SLC0010) staining
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