The product of this gene belongs to the SEC15 family. It is highly similar to the protein encoded by Saccharomyces cerevisiae SEC15 gene. This protein is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Function:
EXOC6 is a component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane.
Subunit:
The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with CNTRL. Interacts with RAB11A in a GTP-dependent manner (By similarity).
Similarity:
Belongs to the SEC15 family.
SWISS:
Q8TAG9
Gene ID:
54536
Database links:
Entrez Gene: 54536 Human
Entrez Gene: 107371 Mouse
Entrez Gene: 50556 Rat
Omim: 609672 Human
SwissProt: Q8TAG9 Human
SwissProt: Q8R313 Mouse
SwissProt: O54923 Rat
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Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (EXOC6) Polyclonal Antibody, Unconjugated (SL14662R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (EXOC6) Polyclonal Antibody, Unconjugated (SL14662R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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