ZNF774 (zinc finger protein 774) is a 483 amino acid protein that localizes to the nucleus and contains 12 C2H2-type zinc fingers and a KRAB domain. One of several members of the Krüppel C2H2-type zinc-finger protein family, ZNF774 is thought to be involved in transcriptional regulation events. The gene encoding ZNF774 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.
Function:
May be involved in transcriptional regulation.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 12 C2H2-type zinc fingers.
Contains 1 KRAB domain.
SWISS:
Q6NX45
Gene ID:
342132
Database links:
Entrez Gene: 342132 Human
SwissProt: Q6NX45 Human
Unigene: 55307 Human
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Sample:Lovo Cell Lysate at 40 ug
Primary: Anti-ZNF774 (SL16479R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 55 kD
Observed band size: 55 kD
Sample:U87mg Cell Lysate at 40 ug
Primary: Anti-ZNF774 (SL16479R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 55 kD
Observed band size: 55 kD
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