This gene encodes a mitochondrially-localized protein that has sequence similarity to prokaryotic beta-lactamases. Many of the residues responsible for beta-lactamase activity are not conserved in this protein, suggesting it may have a different enzymatic function. Increased expression of the related mouse gene was found to be associated with obesity. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Dec 2013]
Function:
LACTB is a protein from the large 39S subunit of the mitochondrial ribosome (mitoribosome). It has some sequence similarity to prokaryotic beta-lactamases but most of the residues that are responsible for the beta-lactamase activity are not conserved between the two proteins. It is expressed predominantly in skeletal muscle. There are two named isoforms.
Subcellular Location:
Mitochondrion
Similarity:
Belongs to the peptidase S12 family.
SWISS:
P83111
Gene ID:
114294
Database links:
Entrez Gene: 114294 Human
Entrez Gene: 80907 Mouse
Entrez Gene: 300803 Rat
Omim: 60888 Human
SwissProt: P83111 Human
SwissProt: Q9EP89 Mouse
Unigene: 410388 Human
Unigene: 157882 Mouse
Unigene: 73451 Rat
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Sample:
liver (Mouse) Lysate at 40 ug
kidney (Mouse) Lysate at 40 ug
Primary: Anti-LACTB (SL16882R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 49 kD
Observed band size: 49 kD
Sample:
liver (Mouse) Lysate at 40 ug
Primary: Anti-LACTB (SL16882R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 49 kD
Observed band size: 49 kD
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