This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011]
Function:
Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis.
Subunit:
Heterooligomer of MSH4 and MSH5. Interacts with HJURP.
Tissue Specificity:
Ubiquitous, but highly expressed in testis, and thymus.
Similarity:
Belongs to the DNA mismatch repair mutS family.
SWISS:
O43196
Gene ID:
4439
Database links:
Entrez Gene: 100139295 Cow
Entrez Gene: 474848 Dog
Entrez Gene: 100050672 Horse
Entrez Gene: 4439 Human
Entrez Gene: 715494 Monkey
Entrez Gene: 17687 Mouse
Entrez Gene: 100270818 Pig
Entrez Gene: 294252 Rat
Omim: 603382 Human
SwissProt: O43196 Human
SwissProt: Q9QUM7 Mouse
SwissProt: Q6MG62 Rat
Unigene: 647011 Human
Unigene: 24192 Mouse
Unigene: 8843 Rat
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Paraformaldehyde-fixed, paraffin embedded (mouse testis tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MSH5) Polyclonal Antibody, Unconjugated (SL17852R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (rat thymus); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MSH5) Polyclonal Antibody, Unconjugated (SL17852R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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