Thyroid hormone receptors are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. The protein encoded by this gene binds thyroid hormone receptor beta, but only in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Function:
Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate and uterus. Low expression in liver, spleen, placenta and ovaries.
Similarity:
Belongs to the HMGN family.
SWISS:
Q15651
Gene ID:
9324
Database links:
Entrez Gene: 515652 Cow
Entrez Gene: 100723034 Guinea pig
Entrez Gene: 100069315 Horse
Entrez Gene: 9324 Human
Entrez Gene: 94353 Mouse
Entrez Gene: 100512571 Pig
Entrez Gene: 113990 Rat
Entrez Gene: 492345 Zebrafish
Omim: 604502 Human
SwissProt: Q3ZBV4 Cow
SwissProt: Q15651 Human
SwissProt: Q9DCB1 Mouse
SwissProt: Q66H40 Rat
Unigene: 77558 Human
Unigene: 244426 Mouse
Unigene: 106652 Rat
| Picture |
Paraformaldehyde-fixed, paraffin embedded (Mouse testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (HMGN3) Polyclonal Antibody, Unconjugated (SL3655R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (Rat lung); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (HMGN3) Polyclonal Antibody, Unconjugated (SL3655R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
|
|
|
