Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. Acts as a remodeling enzyme for cardiolipin, a major membrane polyglycerophospholipid. Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) with a relatively low activity. Required for establishment of the hematopoietic and endothelial lineages.
Subcellular Location:
Endoplasmic reticulum membrane.
Tissue Specificity:
Expressed at higher level in heart, kidney and pancreas than in brain, spleen, liver, lung, small intestine and placenta.
Similarity:
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
SWISS:
Q6UWP7
Gene ID:
253558
Database links:
Entrez Gene: 253558 Human
Entrez Gene: 225010 Mouse
Entrez Gene: 100217396 Pig
Omim: 614241 Human
SwissProt: Q6UWP7 Human
SwissProt: Q3UN02 Mouse
Unigene: 413648 Human
Unigene: 662770 Human
Unigene: 329194 Mouse
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Sample:
Liver(Mouse)Lysate at 40 ug
Kidney (Mouse)Lysate at 40 ug
Primary: Anti-LCLAT1(SL18190R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 49kD
Observed band size: 49kD
Sample:Heart (Mouse)Lysate at 40 ug
Primary: Anti-LCLAT1(SL18190R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 49kD
Observed band size: 49kD
Sample:
Heart (Mouse) Lysate at 40 ug
Heart (Rat) Lysate at 40 ug
Primary: Anti-LCLAT1 (SL18190R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 52 kD
Observed band size: 52 kD
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