ZDHHC13 is a 622 amino acid multi-pass membrane protein that contains one DHHSLCtype zinc finger and six ANK repeats. Expressed as multiple alternatively spliced isoforms, HIP14L functions as a palmitoyltransferase that catalyzes the conversion of palmitoyl-CoA and a protein-cyeteine to an S-palmitoyl protein and CoA and, via this catalytic activity, may be involved in the NFⅹB signaling pathway. The gene encoding HIP14L maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.
Function:
Palmitoyltransferase for HD and GAD2 (By similarity). Mediates Mg(2+) transport.
Subcellular Location:
Golgi apparatus membrane. Cytoplasmic vesicle membrane. Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi vesicles.
Similarity:
Belongs to the DHHC palmitoyltransferase family.
AKR/ZDHHC17 subfamily.
Contains 6 ANK repeats.
Contains 1 DHHSLCtype zinc finger.
SWISS:
Q8IUH4
Gene ID:
54503
Database links:
Entrez Gene: 42596 Chicken
Entrez Gene: 54503 Human
Entrez Gene: 243983 Mouse
Entrez Gene: 365252 Rat
Entrez Gene: 494107 Zebrafish
Omim: 612815 Human
SwissProt: Q8IUH4 Human
SwissProt: Q9CWU2 Mouse
Unigene: 188569 Human
Unigene: 279116 Mouse
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Paraformaldehyde-fixed, paraffin embedded (human colon carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ZDHHC13) Polyclonal Antibody, Unconjugated (SL18474R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (rat stomach tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ZDHHC13) Polyclonal Antibody, Unconjugated (SL18474R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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