Axam2;
DKFZp762A2316;
KIAA1331;
Senp2;
SERP2;
SENP2_HUMAN;
Sentrin specific protease 2;
Sentrin-specific protease 2;
Sentrin/SUMO specific protease SENP2;
Sentrin/SUMO-specific protease SENP2;
SMT3 specific isopeptidase 2;
SMT3-specific isopepti
Cat:
SL19632R
Species Reactivity：
Mouse,(predicted: Human,Rat,)
Immunogen：
KLH conjugated synthetic peptide derived from human SENP2:1-100/589
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Protein: lung(mouse) lysate at 40ug;Primary: rabbit Anti-SENP2(SL19632R) at 1:300; Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 68 kDObserved band size: 63 kDProtein: bone(mouse) lysate at 40ug;Primary: rabbit Anti-SENP2(SL19632R) at 1:300; Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 68 kDObserved band size: 63 kD
SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]
Function: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway.
Subcellular Location: Nucleus > nuclear pore complex. Nucleus membrane. Cytoplasm. Shuttles between cytoplasm and nucleus.
Post-translational modifications: Polyubiquitinated; which leads to proteasomal degradation.
