Rabbit Anti-SLC39A4 antibody

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1600025H15Rik; Acrodermatitis enteropathica zinc deficiency type; Activated in W/Wv mouse stomach 2; AEZ; AU041686; AWMS2; FLJ20327; MGC156705; MGC74741; S39A4_HUMAN; Slc39a4; Solute carrier family 39 member 4; Ssolute carrier family 39 zinc t

Cat:

SL19832R

Species Reactivity：

Human,Rat,

Immunogen：

KLH conjugated synthetic peptide derived from human SLC39A4:281-380/647

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Sample: MCF-7 (human)Cell Lysate at 40 ugPrimary: Anti- SLC39A4 (SL19832R)at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size:66kDObserved band size: 71 kDParaformaldehyde-fixed, paraffin embedded (Rat stomach); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SLC39A4) Polyclonal Antibody, Unconjugated (SL19832R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The encoded protein localizes to cell membranes and is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

Function:
Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability.

Subcellular Location:
Cell membrane. Recycling endosome membrane. Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability.

Tissue Specificity:
Highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum.

DISEASE:
Acrodermatitis enteropathica, zinc-deficiency type (AEZ)

Similarity:
Belongs to the ZIP transporter (TC 2.A.5) family.

SWISS:
Q6P5W5

Gene ID:
55630

Database links:

Entrez Gene: 55630 Human

Entrez Gene: 72027 Mouse

Omim: 607059 Human

SwissProt: Q6P5W5 Human

SwissProt: Q78IQ7 Mouse

Unigene: 521934 Human

Unigene: 276829 Mouse

Picture

Paraformaldehyde-fixed, paraffin embedded (Rat stomach); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SLC39A4) Polyclonal Antibody, Unconjugated (SL19832R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.

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