Rabbit Anti-phospho-PDGFRA (Tyr720) antibody

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PDGF Receptor alpha (phospho Y720); p-PDGF Receptor alpha (phospho Y720); Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a; CD140a antigen; MGC74795; PDGF alpha chain; PDGF-R-alpha; PDGFR 2; PDGFR alp

Cat:

SL12595R

Species Reactivity：

Human,(predicted: Mouse,Rat,Chicken,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthesised phosphopeptide derived from human PDGFRA around the phosphorylation site of Tyr720:RS(p-Y)VI

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $256.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]

Function:
Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.

Subcellular Location:
Membrane.

Tissue Specificity:
Expressed in primary and metastatic colon tumors and in normal colon tissue. Tumors may express a different isoform to that found in normal tissue.

DISEASE:
Note=A chromosomal aberration involving PDGFRA is found in some cases of hypereosinophilic syndrome. Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA).

Similarity:
Belongs to the protein kinase superfamily.
Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain.

SWISS:
P16234

Gene ID:
5156

Database links:

Entrez Gene: 5156 Human

Entrez Gene: 18595 Mouse

Entrez Gene: 25267 Rat

Omim: 173490 Human

SwissProt: P16234 Human

SwissProt: P26618 Mouse

SwissProt: P20786 Rat

Unigene: 74615 Human

Unigene: 221403 Mouse

Unigene: 55127 Rat

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