Rabbit Anti-TGF beta 2 antibody

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Transforming growth factor beta-2 proprotein; TGFB2; TGF B2; BSC 1 cell growth inhibitor; BSC-1 cell growth inhibitor; BSC1 cell growth inhibitor; Cetermin; G TSF; G-TSF; Glioblastoma derived T cell suppressor ; Glioblastoma derived T cell suppressor fact

Cat:

SL20412R

Species Reactivity：

Human,Mouse,Rat,

Immunogen：

KLH conjugated synthetic peptide derived from human TGF beta 2:351-414/414

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Sample: MDA-MB-231 (human)cell Lysate at 40 ugPrimary: Anti- TGF beta2 (SL20412R)at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 50 kDObserved band size: 48 kDSample:Placenta (Mouse)Lysate at 40 ugBladder (Mouse)Lysate at 40 ugPrimary: Anti-TGF beta 2(SL20412R)at 1/300 dilutionSecondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilutionPredicted band size: 50kDObserved band size: 50kDSample: Lane 1: Mouse Heart tissue lysates Lane 2: Rat Heart tissue lysatesPrimary: Anti-TGF beta 2 (SL20412R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 50 kDaObserved band size: 50 kDa

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Transforming growth factor beta s (TGF beta s) were originally discovered due to their ability to promote anchorage-independent growth of rat NRK fibroblasts in the presence of TGF Alpha. It is now realized that TGF beta s mediate many cell-cell interactions that occur during embryonic development. Three TGF beta s have been identified in mammals. TGF beta 1, TGF beta 2 and TGF beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGF beta requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGF beta 3 protein has approximately 80% identity to the mature region of both TGF beta 1 and TGF beta 2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity.

Function:
TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.

Subunit:
Homodimer; disulfide-linked. Heterodimers with TGFB1 and with TGFB3 have been found in bone. Interacts with the serine proteases, HTRA1 and HTRA3. Interacts with ASPN.

Subcellular Location:
Secreted.

Similarity:
Belongs to the TGF-beta family.

SWISS:
P61812

Gene ID:
7042

Database links:

Entrez Gene: 7042 Human

Entrez Gene: 2368 Mouse

Omim: 190220 Human

SwissProt: P21214 Cow

SwissProt: P61812 Human

SwissProt: P27090 Mouse

Unigene: 133379 Human

Unigene: 18213 Mouse

Picture

Sample:
Placenta (Mouse)Lysate at 40 ug
Bladder (Mouse)Lysate at 40 ug
Primary: Anti-TGF beta 2(SL20412R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 50kD
Observed band size: 50kD

Sample:
Lane 1: Mouse Heart tissue lysates
Lane 2: Rat Heart tissue lysates
Primary: Anti-TGF beta 2 (SL20412R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 50 kDa
Observed band size: 50 kDa

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