With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6% of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. The FAM105B gene product has been provisionally designated FAM105B pending further characterization.
Function:
Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex. Plays a key role in innate immune response: required to restrict linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling.
Subunit:
Interacts with RNF31; the interaction is direct.
Subcellular Location:
Cytoplasm.
Post-translational modifications:
Ubiquitinated.
Acetylated.
Phosphorylated.
Similarity:
Belongs to the FAM105 family.
SWISS:
Q96BN8
Gene ID:
90268
Database links:
Entrez Gene: 90268 Human
Entrez Gene: 432940 Mouse
SwissProt: Q96BN8 Human
SwissProt: Q3UCV8 Mouse
Unigene: 406335 Human
Unigene: 309164 Mouse
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Sample:
Liver (Mouse) Lysate at 40 ug
Primary: Anti-FAM105B (SL21613R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 40 kD
Observed band size: 40 kD
Sample:
Liver (Mouse) Lysate at 40 ug
Primary: Anti- FAM105B (SL21613R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 40 kD
Observed band size: 40 kD
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