The X and Y chromosomes are the human sex chromosomes. Chromosome X consists of about 153 million base pairs and nearly 1,000 genes. The combination of an X and Y chromosome lead to normal male development while two copies of X lead to normal female development. There are a number of conditions related to an unsual number and combination of sex chromosomes being inherited. More than one copy of the X chromosome with a Y chromosome causes Klinefelter's syndrome. A single copy of X alone leads to Turner's syndrome. More than 2 copies of the X chromosome, in the absence of a Y chromosome, is known as Triple X syndrome. Color blindness, hemophilia, and Duchenne muscular dystrophy are well known X chromosome-linked conditions which affect males more frequently as males carry a single X chromosome. The CXorf36 gene product has been provisionally designated CXorf36 pending further characterization.
Subcellular Location:
Secreted (Potential).
DISEASE:
Note=Genetic variations in CXorf36 may be associated with susceptibility to autism.
Similarity:
Belongs to the DIA1 family.
SWISS:
Q9H7Y0
Gene ID:
79742
Database links:
Entrez Gene: 79742 Human
SwissProt: Q9H7Y0 Human
Unigene: 98321 Human
经研究：CXorf36蛋白是通过其水解酶活性，在肿瘤的发生、生长或侵袭过程中发挥重要作用。对关于CXorf36基因功能的研究,其在肿瘤组织中的定位、对细胞生物学功能的影响需进一步研究。
文献参考：
Picture
Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,SLC0005) at 37℃ for 20 min;
Incubation: Anti-CXorf36 Polyclonal Antibody, Unconjugated(SL0488R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(SLC0010) staining
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