Rabbit Anti-FAM3B antibody | Sunlong Medical

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C21orf11; PANDER; Cytokine like protein 2 21; PRED44; PANcreatic DERived factor; Protein FAM3B; Protein FAM3B precursor; Family with sequence similarity 3, member B isoform a; FAM3B_MOUSE.

Cat:

SL0711R

Species Reactivity：

Rat,(predicted: Human,Mouse,)

Immunogen：

KLH conjugated synthetic peptide derived from human FAM3B:1-100/235

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Tissue/cell: rat pancreas tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,SLC0005) at 37℃ for 20 min; Incubation: Anti-FAM3B/PANDER Polyclonal Antibody, Unconjugated(SL0711R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(SLC0010) staining

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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FAM3B has delayed effects on beta-cell function, inhibiting basal insulin secretion from a beta-cell line in a dose-dependent manner. [Subcellular Location] Secreted. Note=Localized in discrete vesicular and perinuclear structure. Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis. 2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46. Belongs to the FAM3 family.

Function:
Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.

Subcellular Location:
Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure.

Tissue Specificity:
Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis.

Post-translational modifications:
2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46.
O-glycosylated.

Similarity:
Belongs to the FAM3 family.

SWISS:
Q9D309

Gene ID:
52793

Database links:

Entrez Gene: 54097 Human

Entrez Gene: 52793 Mouse

Omim: 608617 Human

SwissProt: P58499 Human

SwissProt: Q9D309 Mouse

Unigene: 473877 Human

Unigene: 670704 Human

Unigene: 327932 Mouse

胰腺衍生因子（PANcreatic DERived fa*ctor，PANDER）是新发现的一种新型的胰岛细胞因子、由胰岛α细胞和β细胞分泌的一种分泌型细胞因子，与β细胞凋亡密切相关，可以诱导胰岛素分泌β细胞，主要用于糖尿病的研究。 Picture

Tissue/cell: rat pancreas tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,SLC0005) at 37℃ for 20 min;
Incubation: Anti-FAM3B/PANDER Polyclonal Antibody, Unconjugated(SL0711R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(SLC0010) staining

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