Rabbit Anti-PLGF antibody | Sunlong Medical

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Placenta growth factor; PGF; PGFL; PIGF; Placental growth factor vascular endothelial growth factor related protein; PlGF 2; PLGF; PlGF2; PLGF_MOUSE; Vascular endothelial growth factor related protein.

Cat:

SL0280R

Species Reactivity：

Rat,(predicted: Mouse,Pig,)

Immunogen：

KLH conjugated synthetic peptide derived from mouse PLGF:101-158/158

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Sample: Placenta (Rat) Lysate at 30 ugPrimary: rabbit Anti-PLGF (SL0280R) at 1:300 dilution; Secondary: HRP conjugated Goat-Anti-rabbit IgG(SL0295G-HRP) at 1: 5000 dilution; Predicted band size:16 kDObserved band size:16 kD

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]

Function:
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner.

Subunit:
Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF.

Subcellular Location:
Secreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.

Tissue Specificity:
While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.

Post-translational modifications:
N-glycosylated.

Similarity:
Belongs to the PDGF/VEGF growth factor family.

SWISS:
P49764

Gene ID:
18654

Database links:

Entrez Gene: 5228 Human

Entrez Gene: 18654 Mouse

Entrez Gene: 94203 Rat

Omim: 601121 Human

SwissProt: P49763 Human

SwissProt: P49764 Mouse

SwissProt: Q63434 Rat

Unigene: 252820 Human

Unigene: 969 Mouse

Unigene: 6960 Rat

PLGF胎盘生长因子是血管生长因子家族成员之一（又称：胎盘型血管内皮细胞生长因子），是动脉粥样硬化斑块不稳定的主要炎性激活物，因此它可作为ACS患者风险预测的生物学标志物.尿胎盘生长因子水平可预测先兆子痫危险.研究人员发现，在疾病发作前的6到8周，先兆子痫患者尿液中的胎盘生长因子水平急剧下降,这种新的尿检方法使提前1到2个月预测先兆子痫成为可能。亦有研究人员正在从事胎盘生长因子与肺气肿，胃癌，肠癌等方面的研究。 Picture

Sample: Placenta (Rat) Lysate at 30 ug
Primary: rabbit Anti-PLGF (SL0280R) at 1:300 dilution;
Secondary: HRP conjugated Goat-Anti-rabbit IgG(SL0295G-HRP) at 1: 5000 dilution;
Predicted band size:16 kD
Observed band size:16 kD

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