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Home > Product > Antibody > Rabbit Anti-Selenoprotein W antibody
MGC105482; SelW; SEPW1; Selenoprotein W; SELW_RAT; SELW_HUMAN.
Cat:
SL0495R
Species Reactivity：
Rat,(predicted: Human,Mouse,Sheep,)
Immunogen：
KLH conjugated synthetic peptide derived from mouse Selenoprotein W:13-88/88
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Paraformaldehyde-fixed, paraffin embedded (Rat heart); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Selenoprotein W) Polyclonal Antibody, Unconjugated (SL0495R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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Product PDFs
Datasheet:


This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A pseudogene for this locus has been identified on chromosome 10. [provided by RefSeq, May 2017].

Function:
Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency.

Subunit:
Interacts with DPYSL2, PRDX1, YWHAB, YWHAG, HSP70 and HSP90.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Ubiquitously expressed with highest levels in skeletal muscle and heart, moderate levels in brain, spinal cord, thyroid, spleen, prostate, ovary, small intestine and colon, and lowest levels in liver and lymph node.

Similarity:
Belongs to the SelWTH family. SELW subfamily.

SWISS:
P63300

Gene ID:
20364

Database links:




硒蛋白-W（selenoprotein W）和一种存在于多种组织中的18ku硒蛋白P（18ku selenoprotein）。它们具有防止膜结构及生物大分子的氧化损伤；合成并调节DNA表达；促进精子生成、发育及维持其活力；保护内皮细胞和维护肌肉组织的正常功能等广泛的生理作用。该蛋白与人、羊有部分交叉。 Picture

Paraformaldehyde-fixed, paraffin embedded (Rat heart); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Selenoprotein W) Polyclonal Antibody, Unconjugated (SL0495R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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