Rabbit Anti-VCAM1 antibody | Sunlong Medical

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CD 106; CD106; CD106 Antigen; DKFZp779G2333; INCAM 100; MGC99561; Vascular Cell Adhesion Molecule 1; Vascular cell adhesion protein 1; VCAM 1; VCAM-1; INCAM-100; V-CAM 1; VCAM1_HUMAN.

Cat:

SL0920R

Species Reactivity：

Human,Mouse,Rabbit,Sheep,(predicted: Rat,Pig,)

Immunogen：

KLH conjugated synthetic peptide derived from human VCAM-1:651-739/739<Cytoplasmic>

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Sample: VCAM1 protein (Human) at 100 ngPrimary: Anti-VCAM1 (SL0920R) at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 81 kDObserved band size: 78 kD

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Unit:

Price: $220.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]

Function:
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.

Subunit:
Binds to ECMSLVD capsid proteins and acts as a receptor for this virus.

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor.

Tissue Specificity:
Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Expressed in the bone marrow.

Similarity:
Contains 7 Ig-like C2-type (immunoglobulin-like) domains.

SWISS:
P1964

Gene ID:
7412

Database links:

Entrez Gene: 7412 Human

Entrez Gene: 22329 Mouse

Entrez Gene: 25361 Rat

SwissProt: P1964 Human

SwissProt: P29533 Mouse

Picture

Sample: VCAM1 protein (Human) at 100 ng
Primary: Anti-VCAM1 (SL0920R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 81 kD
Observed band size: 78 kD

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Specific References (16) | SL0920R has been referenced in 16 publications.

[IF=4.522] Zhao H et al. miR‐181a/b‐5p ameliorates inflammatory response in monocrotaline‐induced pulmonary arterial hypertension by targeting endocan. J Cell Physiol. 2019 Oct 21. WB ; Rat.

PubMed:31637717

[IF=7.901] Shim W et al. Catechin solubilization by spontaneous hydrogen bonding with poly(ethylene glycol) for dry eyetherapeutics. J Control Release. 2019 May 20. IHSLCP ; Mouse.

PubMed:31121276

[IF=7.901] Shim W et al. Catechin solubilization by spontaneous hydrogen bonding with poly(ethylene glycol) for dry eyetherapeutics. J Control Release. 2019 May 20. IHSLCP ; Mouse.

PubMed:31121276

[IF=5.11] Vendrov, Aleksandr E., et al. "Attenuated Superoxide Dismutase 2 Activity Induces Atherosclerotic Plaque Instability During Aging in Hyperlipidemic Mice." Journal of the American Heart Association 6.11 (2017): e006775. IHSLCF ; Mouse.

PubMed:29079564

[IF=4.87] Lozhkin, Andrey, et al. "NADPH oxidase 4 regulates vascular inflammation in aging and atherosclerosis." Journal of Molecular and Cellular Cardiology (2016). IHSLCF ; Mouse.

PubMed:27986445

[IF=1.93] Tang, Li‐Qin, et al. "The renoprotective effects of berberine and its potential impact on the expression of β‐arrestins and ICAM‐1/VCAM‐1 in streptozocin induced‐diabetic nephropathy rats." Journal of Diabetes (2015). other ;

PubMed:26531813

[IF=5.21] Ma, Yanqin, et al. "Inflammatory responses induced by fluoride and arsenic at toxic concentration in rabbit aorta." Archives of toxicology 86.6 (2012): 849-856. WB ; Rabbit.

PubMed:22422340

[IF=5.23] Kim, Chae Eun, et al. "Effects of silk fibroin in murine dry eye." Scientific Reports 7 (2017): 44364. IHSLCF ; Mouse.

PubMed:28281688

[IF=7.126] Vendrov AE et al.NOXA1-dependent NADPH oxidase regulates redox signaling and phenotype of vascular smooth muscle cell during atherogenesis.Redox Biol. (2018) Redox Biol. 21:101063. IHF ; Mouse.

PubMed:30576919

[IF=16.806] Jianting Yao. et al. Low-Intensity Focused Ultrasound-Responsive Ferrite-Encapsulated Nanoparticles for Atherosclerotic Plaque Neovascularization Theranostics. 2021 Aug 11 IF ; Rabbit.

PubMed:34382370

[IF=2.086] Park EY et al. Sulglycotide ameliorates inflammation in lipopolysaccharide-stimulated mouse macrophage cells by blocking the NF-κB signaling pathway. Immunopharmacol Immunotoxicol. 2019 Jun 23:1-8. WB&ICF ; Mouse.

PubMed:31232125

[IF=2.784] Zhang et al. Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway. (2018) Int.J.Mol.Med. 42:3344-3354 WB ; Human.

PubMed:30272329

[IF=3.213] Tang et al. The renoprotective effects of berberine and its potential impact on the expression of β-arrestins and ICAM-1/VCAM-1 in streptozocin induced-diabetic nephropathy rats. (2015) J.Diabetes. IHSLCP/WB ; rat.

PubMed:26531813

[IF=2.766] Belcher et al. Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction. (2018) PLoS.One. 13:e0196455 IF ; mouse.

PubMed:29694434

[IF=16.834] Bartko, Philipp E., et al. "Effect of Losartan on Mitral Valve Changes After Myocardial Infarction." Journal of the American College of Cardiology 70.10 (2017): 1232-1244. ICC ; Sheep.

PubMed:28859786

[IF=1.28] Mu, Wei, et al. "Expression of vascular cell adhesion molecule-1 in the aortic tissues of atherosclerotic patients and the associated clinical implications." Experimental and therapeutic medicine 10.2 (2015): 423-428. IHSLCP ; Human.

PubMed:26622332