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LSHB_HUMAN; Lutropin subunit beta; Lutropin beta chain; Luteinizing hormone subunit beta (LH-B; LSH-B; LH B; LSH-beta); CGB4; HH23;
Cat:
SL0952R
Species Reactivity：
(predicted: Human,)
Immunogen：
KLH conjugated synthetic peptide derived from human LH:101-141/141
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Sample:293T(Human) Cell Lysate at 30 ugPrimary: Anti-CD200R (SL7351R) at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 16 kDObserved band size: 19 kD
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Product PDFs
Datasheet:


This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008]

Function:
Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.

Subunit:
Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

Subcellular Location:
Secreted.

DISEASE:
Hypogonadism LHB-related (HGON-LHB) [MIM:152780]: Characterized by infertility and pseudohermaphroditism. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the glycoprotein hormones subunit beta family.

SWISS:
P01229

Gene ID:
3972

Database links:

Entrez Gene: 3972 Human

Entrez Gene: 16866 Mouse

Entrez Gene: 25329 Rat

SwissProt: P01229 Human

SwissProt: O09108 Mouse

SwissProt: P01230 Rat



LH和FSH都是垂体前叶产生的，由两条多肽链(即а和β亚单位)经非共价键结合的糖蛋白。LH和FSH都是呈脉冲式分泌，故有较明显的日内和日间变异。
女性月经中期的LH高峰促成排卵，男性LH主要刺激Legdig细胞产生睾丸酮，又协同FSH促进精子成熟。与FSH同时测定，是研究和判断下丘脑 — 垂体 — 性腺轴功能的常规检查方法。LH的测定在预测排卵时间上具有特殊重要意义，它还可用于绝经期检查，不孕症诊断和内分泌治疗的监测等。 Picture

Sample:293T(Human) Cell Lysate at 30 ug
Primary: Anti-CD200R (SL7351R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 16 kD Observed band size: 19 kD
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