he ATP binding cassette (ABC) superfamily of membrane transporters is one of the largest protein classes known, and counts for numerous proteins involved in trafficking of biological molecules across membranes. ABCG4 protein is highly expressed in both human and mouse brain, it is a 646aa molecule in human (chr 11q23) and mouse. It is an integral membrane protein may be involved in macrophage lipid homeostasis. The ABCG4 protein’s abundant expression in brain and close evolutionary relationship to the other members of the subfamily suggests a potential role in cholesterol transport.
Function:
May be involved in macrophage lipid homeostasis.
Subcellular Location:
Membrane; Multi-pass membrane protein (Probable).
Similarity:
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Contains 1 ABC transmembrane type-2 domain.
Contains 1 ABC transporter domain.
SWISS:
Q9H172
Gene ID:
64137
Database links:
Entrez Gene: 64137 Human
Entrez Gene: 192663 Mouse
Entrez Gene: 300664 Rat
Omim: 607784 Human
SwissProt: Q9H172 Human
Unigene: 126378 Human
Unigene: 101876 Mouse
Unigene: 5808 Rat
| Picture |
Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by microwave in sodium citrate buffer (pH6.0) ; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (3% BSA) at RT for 30min; Antibody incubation with (ABCG4) Polyclonal Antibody, Unconjugated (SL1727R) at 1:400 overnight at 4℃, followed by conjugation to the secondary antibody (labeled with HRP)and DAB staining.
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