CaMKI gamma is a Calcium/calmodulin-dependent protein kinase which belongs to a proposed calcium-triggered signaling cascade. In vitro it phosphorylates transcription factor CREB1. It has been proposed that CaMKI gamma is involved in dendritic outgrowth mediated by CaM-dependant protein kinase kinase.
Function:
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 (By similarity).
Subcellular Location:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein.
Tissue Specificity:
Mainly expressed in brain with small amounts in skeletal muscles, kidney, spleen and liver. Strongly expressed in forebrain neocortex, striatum and limbic system.
Post-translational modifications:
May be prenylated on Cys-473.
Similarity:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Contains 1 protein kinase domain.
SWISS:
Q96NX5
Gene ID:
57172
Database links:
Entrez Gene: 57172 Human
Entrez Gene: 215303 Mouse
Entrez Gene: 448849 Pig
Entrez Gene: 171358 Rat
SwissProt: Q96NX5 Human
SwissProt: Q91VB2 Mouse
SwissProt: Q7TNJ7 Rat
Unigene: 199068 Human
Unigene: 40329 Mouse
Unigene: 91453 Rat
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Paraformaldehyde-fixed, paraffin embedded (rat liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Camk1g) Polyclonal Antibody, Unconjugated (SL369R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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