AT-1; Solute carrier family 33, member 1; SLC33A1; ACATN; Acetyl CoA transporter; Acetyl Coenzyme A transporter; AT 1; AT1; Human Angiotensin II Type 1 Receptor; Solute carrier family 33 (acetyl CoA transporter) member 1; Solute carrier family 33 member 1
Cat:
SL0699R
Species Reactivity：
Mouse,(predicted: Human,Rat,)
Immunogen：
KLH conjugated synthetic peptide derived from human SLC33A1:481-549/549
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Protein: heart(mouse) lysates at 30ug; Primary: rabbit Anti-SLC33A1 (SL0669R) at 1:300; Secondary: HRP conjugated Goat-Anti-rabbit IgG(SL0295G-HRP) at 1: 5000; Predicted band size:61 kDObserved band size:61 kD
Acetyl-coenzyme A transportor 1 is required for the formation of O-acetylated (Ac) gangliosides. It is predicted to contain 6 to 10 transmembrane domains, and a leucine zipper motif in transmembrane domain III. Studies indicate that the protein is localized to the cytoplasm.
Function: Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides.
Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable).
Tissue Specificity: Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. With strongest signals in pancreas.
DISEASE: Defects in SLC33A1 are the cause of spastic paraplegia autosomal dominant type 42 (SPG42) [MIM:612539]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body
Similarity: Belongs to the SLC33A transporter family.
